Synthesis, characterization and cytotoxicity appraisal of original 1, 2, 3-Triazole derivatives, against breast cancer cell lines (MDA-MB-231)

Authors

  • Mohammed Khalaf Mohammed University of Basrah
  • Zainab Al-Shuhaib
  • Ali A. A. Al-Shawi

DOI:

https://doi.org/10.13171/mjc941911161021mkm

Abstract

The present study established the efficient separate synthesis of four unique 1, 2, 3-triazole derivatives (M1, M2, M3, M4) via conducting 1,3-dipolar cycloaddition of N-((4-azidophenyl) sulfonyl) acetamide, with substituted N-phenylmaleimide. FTIR, 1H NMR, 13C NMR, and mass spectra were utilized for the characterization of the triazoles. The cytotoxic activities of these compounds, with regards to breast cancer cell lines (MDA-MB-231), were then evaluated. The cytotoxicity pre-screening outcomes for 100 µM portrayed a variety of actions, while the IC50 values with concentrations of 0-500 µM for 48 hours, the results are 2.542, 2.929, 2.429, and 2.864 µM for the compounds M1, M2, M3, and M4 respectively. Remarkably, the M2 and M4 para-substituted compounds exhibited superior IC50 values, in comparison to the M1 and M3 ortho-substituted compounds. This suggests that the M1 and M3 compounds have the potential to perform as against breast cancer.

Author Biography

Mohammed Khalaf Mohammed, University of Basrah

Department of Chemistry, College of Education for pure sciences, University of Basrah, Iraq

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Published

2019-11-15

Issue

Section

Organic Chemistry