Diastereoselective Synthesis of some pyrrolidin-2-ones azasugars and study of their stereochemistry

Authors

  • Chahrazed Benhaoua Université de Tiaret , département de physique , faculté sciences de la matière
  • Mustapha Rahmouni Laboratoire synthèse et catalyse, LSCT, Université Ibn Khaldoun, Tiaret, 14000.Algeria ;
  • Hadj Benhaoua 3 Laboratoire de Synthèse Organique Appliquée LSOA, Université d'Oran 1, Ahmed Ben Bella, Oran 31000.

DOI:

https://doi.org/10.13171/mjc8119021922cb

Abstract

The microwave-promoted one-pot multicomponent synthesis of substituted pyrrolidinols using a bifunctional sugar-derived hydroxy-[gamma]-lactone component of amine component or cyanide group is reported. Clean reaction profile, easy work-up procedure, excellent yields and short reaction times are some remarkable features of this method.This modular approach features the in situ-generation of iminium ions intermediate that allows the diastereoselective assembly of the diverse pyrrolidinones efficiently under microwave irradiation has been used.

Author Biographies

Chahrazed Benhaoua, Université de Tiaret , département de physique , faculté sciences de la matière

Département de physique , faculté des sciences de la matière

Mustapha Rahmouni, Laboratoire synthèse et catalyse, LSCT, Université Ibn Khaldoun, Tiaret, 14000.Algeria ;

Departement de chimie, Faculté Science de la matière.

Hadj Benhaoua, 3 Laboratoire de Synthèse Organique Appliquée LSOA, Université d'Oran 1, Ahmed Ben Bella, Oran 31000.

Deparetement de chimie, université d'Oran 1, Ahmed Ben Bella, Oran 31000.

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Published

2019-02-19

Issue

Section

Organic Chemistry