Synthesis of some new 5-amino-3-(substituted-amino)-6-(fluoro/ nitro)aryl-1,2,4-triazine derivatives as lamotrigine analogs and their evaluation in vitro as antibacterial agents

Authors

  • Abdulrahman Salim Alharbi Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, Saudi Arabia
  • Nawaa Ali Alshammari Department of Chemistry, Faculty of Science, Northern Borders University, Rafha, Saudi Arabia

DOI:

https://doi.org/10.13171/mjc861907296asa

Abstract

Some new fluorine-substituted 3,5-disubstituted amino-1,2,4-triazines have been obtained from aryl-amination of 2,2,2-trifluoro-N-[2-(5-hydroxy-3-thioxo-2,3-dihydro-1,2,4-triazin-6-yl)-4-nitrophenyl] acetamide followed by ammonolysis to produce N-(2-(5-amino-3-(arylamino)-1,2,4-triazin-6-yl)-4-nitrophenyl)-2,2,2-trifluoroacetamides which reacted with N-phenylthiourea. The structures of products were deduced from their elemental analysis and spectral measurements. The new lamotrigine analogs were evaluated in vitro as antibacterial. Interestingly, some compounds showed interesting activity against the Bacillus subtilis, Streptococcus faecalis, Micrococcus luteus, and Staphylococcus aureus bacteria.

Author Biography

Abdulrahman Salim Alharbi, Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, Saudi Arabia

Department of Chemistry

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Published

2019-07-28

Issue

Section

Organic Chemistry