Synthesis of amide-spacered dimers of ursolic and oleanolic acid


  • Sophie Hoenke Martin-Luther Universität Halle-Wittenberg
  • Isabell Wiengarn Martin-Luther Universität Halle-Wittenberg
  • Immo Serbian Martin-Luther Universität Halle-Wittenberg
  • Ahmed Al-Harrasi University of Nizwa
  • René Csuk Martin-Luther Universität Halle-Wittenberg



Transdermal therapeutic systems can release drug substances slowly and in a controlled manner from a drug depot. To provide a slow-release form of ursolic and oleanolic acid amide-spacered dimers were synthesized from the parent acids and diamines of variable chain lengths. These dimers were assayed in sulforhodamine B (SRB) assays for their cytotoxicity since as a pre-requisite for their use in slow-release forms these substances must not exert any unfavorable side-effects such as cytotoxicity. As a result of long term incubation up to 96 hours, none of these compounds showed any significant cytotoxicity in sulforhodamine B assays.

Author Biography

René Csuk, Martin-Luther Universität Halle-Wittenberg

Organic ChemistryHead of Department


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Medicinal Chemistry