Direct arylation and Suzuki-Miyaura coupling of imidazo[1,2-a]pyridines catalyzed by (SIPr)Pd(allyl)Cl complex under microwave-irradiation

Authors

  • Abdelmoula El Abbouchi Euromed Research Center, Euromed Faculty of Engineering, Euromed University of Fes (UEMF), Route de Meknes, 30000 Fés
  • Jamal Koubachi Faculté Polydisciplinaire de Taroudant, Université Ibn Zohr d'Agadir, B.P 271, 83000 Taroudant
  • Nabil El Brahmi
  • Said El Kazzouli

DOI:

https://doi.org/10.13171/mjc1911271124sek

Abstract

A short and practical arylation of imidazo[1,2-a]pyridine and imidazole derivatives with aryl halides or aryl boronic acids as coupling partners was successfully carried out using phosphine-free (SIPr)Pd(allyl)Cl as the catalyst [SIPr: (N,N’-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene)] ((SIPr)Pd(allyl)Cl complex). 3,6-disubstituted imidazo[1,2-a]pyridine and 5-substituted imidazole compounds were obtained in good to excellent yields in only 1h under microwave-assisted C-H arylation and Suzuki-Miyaura coupling reaction conditions.

Author Biographies

Abdelmoula El Abbouchi, Euromed Research Center, Euromed Faculty of Engineering, Euromed University of Fes (UEMF), Route de Meknes, 30000 Fés

Euromed Faculty of Engineering

Jamal Koubachi, Faculté Polydisciplinaire de Taroudant, Université Ibn Zohr d'Agadir, B.P 271, 83000 Taroudant

Faculté Polydisciplinaire de Taroudant

Nabil El Brahmi

Euromed Research Center, Euromed Faculty of Engineering, Euromed University of Fes (UEMF), Route de Meknes, 30000 Fés

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Published

2019-11-27

Issue

Section

Organic Chemistry