Coumarin derivatives: Synthesis and cation binding properties

Authors

  • Olfa Naouali Laboratory of Applied Chemistry and Natural Substances Resources and Environment, Faculty of Sciences, University of Carthage, Zarzouna-Bizerta, 7021, Tunisia
  • Rached Frija Heterocyclic and Organometallic Chemistry Laboratory, Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif, 2050, Tunisia
  • Wissal Elgabsi Heterocyclic and Organometallic Chemistry Laboratory, Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif, 2050, Tunisia
  • Naceur Hamdi Chemistry Department, College of Science and Arts, Qassim University, Al-Rass, Kingdom of Saudi Arabia
  • Lassaad Baklouti Laboratory of Applied Chemistry and Natural Substances Resources and Environment, Faculty of Sciences, University of Carthage, Zarzouna-Bizerta, 7021, Tunisia

DOI:

https://doi.org/10.13171/mjc.3.5.2014.12.05.23.05

Abstract

Coumarin derivatives were easily prepared starting from 7-hydroxy 4-methyl-2H-chromen-2-one with 40% formaldehyde and suitable secondary amines in 95% ethanol in rather good yield. The structures of all compounds were confirmed via spectroscopic techniques IR, 1H NMR, 13C NMR, mass spectra and elemental analysis. The complexing properties of the coumarin derivatives toward alkali metal, alkaline earth metal, some transition metals and some heavy metal cations have been investigated in methanol by means of UV spectrophotometry absorption and conductivity methods. Thus, the stoichiometry of the complexes formed and their stability constants were determined.

References

- J. R. Dimmock, P. Kumar, Curr. Med. Chem. 1997, 4, 1-22.

- H. I. Gul, T. Ojanen, O. Hanninen; Biol. Pharm. Bull. 2002, 25, 1307-1310.

- H. I. Gul, T. Ojanen, J. Vepsalainen, M. Gul, E. Erciyas, O. Hanninen ; Arzneimittelforschung, 2001, 51, 72-75.

- F. Gul, M. Gul, S. Ozturk, K. O. Yerdelen, Arch. Pharm. (Weinheim), 2005, 338, 335-338.

- E. Mete, C. Ozelgul, C. Kazaz, D. Yurdakul, F. Sahin, H. I. Gul, Arch. Pharm. Chem. Life Sci., 2010, 343, 291-300.

- H. I. Gul, M. Gul, E. Erciyas, J. Appl. Toxicol., 2003, 23, 53-57.

- M. Gul, H. I. Gul, U. Das, O. Hanninen, Arzneimittelforschung, 2005, 55, 332-337.

- H. I. Gul, K. O. Yerdelen, M. Gul, U. Das, B. Pandit, P. K. Li, H. Secen, F. Sahin, Arch. Pharm. (Weinheim), 2007, 340, 195-201.

- H. I. Gul, U. Das, B. Pandit, P. K. Li, Arzneimittelforschung, 2006, 56, 850-855.

-H. I. Gul, K. O. Yerdelen, U. Das. M. Gul, B. Pandit, J. R. Dimmock, Chem. Pharm. Bull. (Tokyo), 2008, 56, 1675-1681.

-M. Gul, E. Mete, M. Atalay, M. Arik, H. I. Gul, Arzneimmittelforschung, 2009, 59, 364-369.

-E. Mete, H. I. Gul, R. Cetin-Atalay, U. Das, E. Sahin, M. Gul, C. Kazaz, J. R. Dimmock, Arch. Pharm. Chem. Life Sci., 2011, 344, 333-339.

Published

2014-12-05

Issue

Section

Environmental Chemistry