Novel 2-mercaptobenzimidazole derivatives: synthesis and evaluation of its antibacterial and antioxidant activities

Authors

  • Latifa El Ouasif University Mohammed V Rabat- Faculty of Sciences Rabat
  • Abdelhakim Bouyahya University Mohammed V Rabat- Faculty of Sciences Rabat
  • Rachid Zniber
  • Mostafa El Ghoul University of Mohammed V - Faculty of Sciences Rabat
  • Redouane Achour University of Mohammed V - Faculty of Sciences Rabat
  • Hind Chakchak National Centre for Scientific and Technical Research, Rabat, Morocco
  • Ahmed Talbaoui University of Mohammed V - Faculty of Sciences Rabat
  • Houria El Boury University of Mohammed V - Faculty of Sciences Rabat
  • Nadia Dakka University of Mohammed V - Faculty of Sciences Rabat
  • Youssef Bakri University of Mohammed V - Faculty of Sciences Rabat

DOI:

https://doi.org/10.13171/mjc63/01704032355-elghoul

Abstract

In the present study, a series of novel 2-mercapto-benzimidazolium were synthesized from 2-mercapto-benzimidazole with hydrocarbon chains. All compounds obtained are reported for the first time, and the structures of these compounds were confirmed by means of 1H-NMR, 13C-NMR and mass spectrometry. The newly synthesized compounds were subjected to in vitro biological evaluation. The antibacterial activity was evaluated will diffusion assay and density optic method. The antioxidant activity was carried out using DPPH free radical scavenging assay. The result indicated that some compounds show convincing antibacterial activities against two microorganisms: Escherichia coli and Staphylococcus aureus. While, these molecules have not shown interesting antioxidant effects.

Author Biographies

Latifa El Ouasif, University Mohammed V Rabat- Faculty of Sciences Rabat

Departement of Chemistry

Abdelhakim Bouyahya, University Mohammed V Rabat- Faculty of Sciences Rabat

Departement of Biology

Mostafa El Ghoul, University of Mohammed V - Faculty of Sciences Rabat

Departement of Chemistry

Redouane Achour, University of Mohammed V - Faculty of Sciences Rabat

Departement of Chemistry

Hind Chakchak, National Centre for Scientific and Technical Research, Rabat, Morocco

UATRS

Ahmed Talbaoui, University of Mohammed V - Faculty of Sciences Rabat

Departement of biology

Nadia Dakka, University of Mohammed V - Faculty of Sciences Rabat

Departement of Biology

Youssef Bakri, University of Mohammed V - Faculty of Sciences Rabat

Departement of Biology

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Published

2017-04-03

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Section

Organic Chemistry