Antimicrobial anthraquinones and triterpenoid isolated from Morinda geminata DC (Rubiaceae)


  • Abdoulaye Gassama Université Assane seck de Ziguinchor, Laboratoire de chimie et physique des matériaux
  • Oumar Sambou Université Assane seck de Ziguinchor, Laboratoire de chimie et physique des matériaux Université Alioune diop de Bambey UFR SATIC département de chimie, Sénégal
  • Moussa Karé Université Alioune diop de Bambey UFR SATIC département de chimie, Sénégal
  • Dame Gambe Université Assane seck de Ziguinchor, Laboratoire de chimie et physique des matériaux
  • Michael Rivard Université Paris Est, Electrochimie et Synthèse Organique, ICMPE (UMR 7182), CNRS, UPEC, 94320 Thiais, France
  • Thierry Martens Université Paris Est, Electrochimie et Synthèse Organique, ICMPE (UMR 7182), CNRS, UPEC, 94320 Thiais, France
  • Isabelle Lachaise Université Paris Est, Plateforme Chromatographie Analytique et Préparative, ICMPE (UMR 7182), CNRS, UPEC 94320 Thiais, France



Morinda geminata DC is a plant of the traditional Senegalese pharmacopoeia, the leaves of which are used in the treatment of various diseases. The phytochemical investigation of its leaves and roots resulted in the isolation of the triterpenoid ursolic acid 6, and five known anthraquinones analogues: nordamnacanthal 1, damnacanthal 2, damnacanthol 3, lucidin-ω-ethyl ether 4, and anthraquinone 5. The isolated compounds were characterized by NMR and mass-spectrometry and were evaluated for their antimicrobial properties. Compounds 1 and 4 displayed significant antimicrobial activities towards Staphylococcus aureus. The present study constitutes the first phytochemical examination of the leaves and roots of Morinda geminata DC.


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