Synthesis of new analogs of 3-methyl-[1,2,4] triazolo [3,4-a] phthalazines via Suzuki coupling and evaluation of their anticancer and antimicrobial activity

Authors

  • Gollapudi Ravi Kumar 1 - Acharya Nagarjuna University, Department of Chemistry, Nagarjuna Nagar-522510, Guntur, Andhra Pradesh, India 2- Government Degree College, Department of Chemistry, Husnabad-505467, Telangana, India.
  • Chandra Mohan Kurmarayuni dept of chemistry
  • Manideepa Indupalli Department of Botany & Microbiology, Nagarjuna Nagar-522510, Guntur, Andhra Pradesh, India
  • Ramya Krishna Pallapati Dept. of Chemistry, Acharya Nagarjuna University, NNAGAR-522510
  • Hari Babu Bollikolla Associate Professor, Dept. of Chemistry, Acharya Nagarjuna University, NNAGAR-522510

DOI:

https://doi.org/10.13171/mjc841905257hbb

Abstract

A series of new N-aryl substituted phenyl acetamide analogs of 3-methyl-[1,2,4] triazolo[3,4-a] phthalazines were synthesized starting from commercially available, in-expensive phthalic anhydride in good yields (65-75 %) via Suzuki Coupling. These compounds were tested for inhibition activity against HCT 116 cancer cell line by using MIT assay. Among the library of compounds, N-(3-methoxyphenyl)-2-(4-(3-methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)phenyl) acetamide followed by 2-(4-(3-methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)phenyl)-N-(m-tolyl) acetamide and  N-(3-chlorophenyl)-2-(4-(3-methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)phenyl) acetamide  were found to be active compounds with IC50 of 70 to and 90 µg mL-1. Further, the compounds were also screened for their antimicrobial activities.

Author Biographies

Gollapudi Ravi Kumar, 1 - Acharya Nagarjuna University, Department of Chemistry, Nagarjuna Nagar-522510, Guntur, Andhra Pradesh, India 2- Government Degree College, Department of Chemistry, Husnabad-505467, Telangana, India.

Chemistrylecturer

Chandra Mohan Kurmarayuni, dept of chemistry

chemistryscholar

Manideepa Indupalli, Department of Botany & Microbiology, Nagarjuna Nagar-522510, Guntur, Andhra Pradesh, India

botany & microbiologyscholar

Ramya Krishna Pallapati, Dept. of Chemistry, Acharya Nagarjuna University, NNAGAR-522510

Research scholarDept. of Chemistry,Acharya Nagarjuna University,NNAGAR-522510

Hari Babu Bollikolla, Associate Professor, Dept. of Chemistry, Acharya Nagarjuna University, NNAGAR-522510

Dept. of chemistry,Assoc professor

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Published

2019-05-25

Issue

Section

Organic Chemistry