DNA binding and biological activity of mixed ligand complexes of Cu(II), Ni(II) and Co(II) with quinolones and N donor ligand

Authors

  • S.M M Akram Islamia College Srinagar Jammu And Kashmir
  • Aijaz A Tak Islamia college Srinagar
  • Peerzada G Mustafa university of Kashmir
  • Javaid A Parray university of Kashmir

Abstract

 AbstractMixed ligand complexes of  Cu(II), Ni(II) and Co(II) have been synthesized by using levofloxacin and bipyridyl and characterized using spectral and analytical techniques. The binding behavior of the Ni(II) and Cu(II) complexes with herring sperm DNA(Hs-DNA) were determined using electronic absorption titration, viscometric measurements and cyclic voltammetry measurements. The binding constant calculated  for Cu(II) and Ni(II) complexes are 2.0 x 104 and 4.0 x 104 M-1 respectively. Detailed analysis reveals that these metal complexes interact with DNA through intercalative binding mode. The nuclease activity of  Cu(II) and Ni(II) complexes with ct-DNA was carried out using agarose gel electrophoresis technique. The antioxidant activities for the synthesized complexes have been tested and the antibacterial activity for Ni(II) complex was also checked.Key words: Intercalation, hypochromism, red shift and  peak potential.

Author Biographies

S.M M Akram, Islamia College Srinagar Jammu And Kashmir

ASSISTANT PROFESSOR DEPARTMENT OF CHEMISTRY

Aijaz A Tak, Islamia college Srinagar

Assistant professor Department of Chemistry

Peerzada G Mustafa, university of Kashmir

Professor Department of Chemistry

Javaid A Parray, university of Kashmir

Research Scholar CORD

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Published

2015-10-06

Issue

Vol. 4 No. 5 (2015)

Section

Bioinorganic Chemistry

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