Click chemistry approach to a series of calcitriol analogues with heterocyclic side chains

Authors

  • Zoila Gándara Departamento de Química Orgánica, Facultad de Química and Instituto de Investigación Biomedica (IBI), University of Vigo, Campus Lagoas de Marcosende, 36310 Vigo, Spain
  • Pedro-Lois Suárez Departamento de Química Orgánica, Facultad de Química and Instituto de Investigación Biomedica (IBI), University of Vigo, Campus Lagoas de Marcosende, 36310 Vigo, Spain
  • Alioune Fall Laboratoire de Chimie de Coordination Organique (LCCO), Département de Chimie, Faculté des Sciences et Techniques: Université Cheikh Anta Diop de Dakar, Sénégal
  • Massène Sène Laboratoire de Chimie de Coordination Organique (LCCO), Département de Chimie, Faculté des Sciences et Techniques: Université Cheikh Anta Diop de Dakar, Sénégal
  • Ousmane Diouf Laboratoire de Chimie de Coordination Organique (LCCO), Département de Chimie, Faculté des Sciences et Techniques: Université Cheikh Anta Diop de Dakar, Sénégal
  • Mohamed Gaye Laboratoire de Chimie de Coordination Organique (LCCO), Département de Chimie, Faculté des Sciences et Techniques: Université Cheikh Anta Diop de Dakar, Sénégal
  • Generosa Gómez Departamento de Química Orgánica, Facultad de Química and Instituto de Investigación Biomedica (IBI), University of Vigo, Campus Lagoas de Marcosende, 36310 Vigo, Spain
  • yagamare fall Departamento de Química Orgánica, Facultad de Química and Instituto de Investigación Biomedica (IBI), University of Vigo, Campus Lagoas de Marcosende, 36310 Vigo, Spain

Abstract

We report a straightforward synthesis of a series of novel calcitriol analogues from vitamin D2with some modification of the procedures described by Calverley and Choudhry. This approach allows the large scale synthesis of a late-stage intermediate common to all the analogues of the series.This intermediate was successfully employed to synthesize a huge number of calcitriol analogues using a “click†chemistry approach. 

References

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Published

2016-04-06

Issue

Vol. 5 No. 2 (2016)

Section

Organic Chemistry

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