Green and efficient method for the synthesis of 1,5-benzodiazipines using phosphate fertilizers as catalysts under free solvent

Authors

  • Sibous Sibous
  • Touriya Ghailane
  • Serrar Houda
  • Rachida Ghailane
  • Said Boukhris
  • Abdelaziz Souizi

DOI:

https://doi.org/10.13171/mjc61/01701181035/souizi

Abstract

Three-component reaction in one pot transformation of aldehydes, ethylacetoacetate and o-phenylenediamine was employed for the synthesis, under solvent-free, of 1,5-benzodiazepine derivatives using fertilizers mono-ammonium phosphate (MAP), di-ammonium Phosphate (DAP) and triple super phosphate (TSP) as safe, clean, and recyclable catalysts. The synthesis method seems to be operationally simple and provides access to a variety of 1,5-benzodiazepines with excellent yields in a short reaction time.

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Published

2017-01-17

Issue

Vol. 6 No. 3 (2017)

Section

Catalysis Chemistry

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