Potentiometric Membrane Sensors for Levamisole Determination

Authors

  • Natalia Zubenya Eastern European National University, Voli av., 13, 43025 Lutsk,
  • Natalia Zubenya Eastern European National University, Voli av., 13, 43025 Lutsk,
  • Zholt Kormosh Eastern European National University, Voli av., 13, 43025 Lutsk, http://orcid.org/0000-0001-6018-8787
  • Diana Saribekova Kherson National Technical University, Beryslavske av., 24, 73008 Kherson,
  • Diana Saribekova Kherson National Technical University, Beryslavske av., 24, 73008 Kherson,
  • Sergei Sukharev State High Educational Establishment "Uzhgorod National University", Pidgirna str., 46, 88000 Uzhgorod,
  • Sergei Sukharev State High Educational Establishment "Uzhgorod National University", Pidgirna str., 46, 88000 Uzhgorod,

DOI:

https://doi.org/10.13171/mjc61/016111516/kormosh

Abstract

The ion pair (IP) of levamisole with BiI4 - (SbI4 - ) for the levamisole-selective sensor with a PVC membrane containing - ions were developed. Thermal behavior of obtained IP was investigated by differential thermal analysis that would show the thermal stability and the character of the decomposition of the complex. The thermolysis of Lev+BiI4 - IP undergoes three stages that fit a theoretical interpretation. The linearity ranges of levamisole sensors function are 7.9 ×10-6 – 1×10-1 (7.9 ×10-5 – 1×10-1 ) M. The Nernstian slope of 50.6 – 53.4 mV pC−1 and detection limit of 5.0 × 10−5 – 1.5 × 10−4) M. The working range of pH is 2.8 – 6.0. The efficiency of the use of electrodes for levamisole content control in pharmaceutical preparations was shown by direct potentiometry and potentiometric titration methods.

Author Biography

Zholt Kormosh, Eastern European National University, Voli av., 13, 43025 Lutsk,

Chair of the Department, Professor

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Published

2016-11-15

Issue

Vol. 6 No. 2 (2017)

Section

Analytical Chemistry

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