First Description of a Guanidine-embedded Pillar[5]arene: Opening New Avenues for Biological Applications
DOI:
https://doi.org/10.13171/mjc62/01701171722-meguellatiAbstract
Guanidine functionality embedded in macrocyclic framework provides intriguing and tunable chemical and physical characteristics to molecular structures. We describe in this paper the first example of guanidine-containing pillar[5]arene and their potential applications in biology and material science. The reaction of O-alkylated p-aminopillar[5]arene with guanylating reagent, amidinopyrazole hydrochloride, gives first ever synthesis of a new generation of guanidine-embedded pillararene 2 under mild reaction conditions.References
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