Highly diastereoselective synthesis of N-substituted 4-(diethoxyphosphoryl)-pyrrolidines-3-carboxylate starting from tetraethyl methylenediphosphonate

Authors

  • Maha Ameur Department of Chemistry, University of Tunis El Manar, Faculty of Science, Campus, 2092 Tunis, Tunisia
  • Aicha Arfaoui Department of Chemistry, University of Tunis El Manar, Faculty of Science, Campus, 2092 Tunis, Tunisia
  • Jihene Ben Kraiem Department of Chemistry, University of Tunis El Manar, Faculty of Science, Campus, 2092 Tunis, Tunisia
  • Salem S. Al-Deyab Department of Chemistry - College of Science, King Saud University B.O. BOX. 2455 Riaydh, 11451-Saudi Arabia
  • Hassen Amri Department of Chemistry, University of Tunis El Manar, Faculty of Science, Campus, 2092 Tunis, Tunisia

DOI:

https://doi.org/10.13171/mjc.2.1.2012.29.07.16

Abstract

 This paper describes a convenient synthesis of novel series of 3,4-disubstituted pyrrolidines based on the aza-Michael addition of primary amines to 3,4-difunctionalized-1,3-diene followed by an intramolecular cyclization.

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Published

2012-07-29

Issue

Vol. 2 No. 1 (2012)

Section

Organic Chemistry

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