Relative cytotoxicity of complexes of platinum(II) and palladium(II) against pure cell culture Paramecium caudatum and human cell lines A431 and HaCaT

Authors

  • Aleksei Vladimirovich Eremin Saint Petersburg State Institute of Technology (Technical University) http://orcid.org/0000-0003-3325-187X
  • Roman Vladimirovich Suezov Saint Petersburg State Institute of Technology (Technical University) Institute of Cytology Russian Academy of Science
  • Polina Sergeevna Grishina
  • Alexander Ivanovich Ponyaev
  • Nicolay Leonidovich Medvedskiy

DOI:

https://doi.org/10.13171/mjc71/01803131026-eremin

Abstract

The results of cytotoxicity cis-diamine mono- and binuclear complexes of platinum(II) and palladium(II) are presented. The cytotoxicity was investigated by the method of biotesting with Paramecium caudatum and by MTT-assay with human cells: epidermoid carcinoma A431 and minimal transformed aneuploid keratinocytes HaCaT. Cytotoxicity of complexes towards protists is higher than against human cells, however, comparatively, HaCaT is more sensitive than A431 by the treatment all complexes. It is noted that cytotoxicity of palladium(II) complexes is higher than the analogues with platinum(II).

Author Biographies

Aleksei Vladimirovich Eremin, Saint Petersburg State Institute of Technology (Technical University)

Department of Inorganic Chemistry, Assistant Professor

Roman Vladimirovich Suezov, Saint Petersburg State Institute of Technology (Technical University) Institute of Cytology Russian Academy of Science

Department of Inorganic Chemistry, PhD

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Published

2018-04-09

Issue

Vol. 7 No. 1 (2018)

Section

Bioinorganic Chemistry

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