Synthesis, characterization and antibacterial activity of bis-amidrazones and bis-triazolones derivatives

Authors

  • Salwa Hamzaoui Laboratoire de Chimie Appliquée : Hétérocycles, Corps Gras et Polymères Faculté des Sciences de Sfax, Université de Sfax, 3018 Sfax, Tunisia.
  • Adel Ben Salem Laboratoire de Chimie Appliquée : Hétérocycles, Corps Gras et Polymères Faculté des Sciences de Sfax, Université de Sfax, 3018 Sfax, Tunisia.
  • Anis Ben Hsouna Biopesticides Team (LPIP), Centre of Biotechnology of Sfax, University of Sfax, P.O. Box « 1177 » 3018 Sfax, Tunisia
  • Najla Chaari Laboratoire d’Environnement et des sciences des Matériaux, Faculté des Sciences de Sfax, Université de Sfax, 3018 Sfax, Tunisia.
  • Mohamed Trigui Biopesticides Team (LPIP), Centre of Biotechnology of Sfax, University of Sfax, P.O. Box « 1177 » 3018 Sfax, Tunisia
  • Maxime Mourer SRSMC, UMR 7565 Nancy Université-CNRS ; Groupe d’Etude des Vecteurs Supramoléculaire du Médicament, Faculté de Pharmacie, 5, rue Albert Lebrun, BP 80403, 54001 Nancy Cedex, France.
  • Mohamed Kossentini Laboratoire de Chimie Appliquée : Hétérocycles, Corps Gras et Polymères Faculté des Sciences de Sfax, Université de Sfax, 3018 Sfax, Tunisia.

DOI:

https://doi.org/10.13171/mjc.1.5.2012.04.04.18

Abstract

 We present a new method for the synthesis of bis-triazolones 3, which result from the processing of novel bis-amidrazones 2 with ethyl chloroformate. The bis-amidrazones 2 are prepared by the reaction of the N1-tosylhydrazonates 1 with two equivalents of aliphatic diamine. The structures of the new products were determined through IR, 1H and 13C NMR studies as well as elemental analysis. The molecular structure of the compound 3c was also determined via an X-ray analysis. The antimicrobial activity of the synthesized compounds was evaluated against a panel of 09 bacterial strains using broth microdilution methods. Results showed that compounds exhibited moderate to strong antibacterial activity against the tested species.

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Published

2012-04-04

Issue

Vol. 1 No. 5 (2012)

Section

Bioinorganic Chemistry

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