New polyoxygenated polyketide from pathogenic fungus Cylindrocarpon destructans with α-glycosidase inhibitory activity


  • Dilfaraz Khan Institute of Chemical Sciences, Gomal University, D.I.Khan, KPK, Pakistan
  • Shahid Ullah Khan
  • Shah Iram Niaz
  • Muhammad Haroon
  • Syed Badshah
  • Shafiullah Khan
  • Salahud Din
  • Lui Lan



Phytochemical investigation on pathogenic fungus Cylindrocarpon destructans isolated form Meconopsisgrandis plant led to the isolation of one new polyoxygenated polyketides, namely cylindrocarpolide A along with five known compounds. The structures of the isolated compounds were elucidated by 1D and 2D NMR and mass spectroscopic data analysis. The isolated compounds were evaluated for α-glycosidase inhibition activity. The compounds isolated compounds were found to have strong to weak inhibition against the α-glycosidase enzymes

Author Biography

Dilfaraz Khan, Institute of Chemical Sciences, Gomal University, D.I.Khan, KPK, Pakistan

Lecturere, Institute of Chemical Sciences, Gomal University, D.I.Khan, KPK, Pakistan


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