An expedient approach for the synthesis and the anti-acetylcholinesterase activity evaluation of 6H-benzimidazol[1,2-c][1,3,2]benzoxazaphosphorine 2-(4-methoxyphenyl)-2-sulfide derivatives from 4-mercapto-2H-chromene-2-thione

Authors

  • Imen Zghab Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité (CHPNR), Equipe Chimie Bio-organique et Produits Naturels, Département de Chimie, Faculté des Sciences de Monastir, Université de Monastir, Avenue de l’Environnement, 5019 Monastir Tunisie
  • Belsem Trimeche Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité (CHPNR), Equipe Chimie Bio-organique et Produits Naturels, Département de Chimie, Faculté des Sciences de Monastir, Université de Monastir, Avenue de l’Environnement, 5019 Monastir Tunisie
  • Anis Romdhane Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité (CHPNR), Equipe Chimie Bio-organique et Produits Naturels, Département de Chimie, Faculté des Sciences de Monastir, Université de Monastir, Avenue de l’Environnement, 5019 Monastir Tunisie
  • David Touboul Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
  • Hichem Ben Jannet Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité (CHPNR), Equipe Chimie Bio-organique et Produits Naturels, Département de Chimie, Faculté des Sciences de Monastir, Université de Monastir, Avenue de l’Environnement, 5019 Monastir Tunisie

DOI:

https://doi.org/10.13171/mjc.1.3.2011.03.12.23

Abstract

A new efficient route for the synthesis of substituted 6H-benzimidazol[1,2-c][1,3,2] benzoxazaphosphorine 2-(4-methoxyphenyl)-2-sulfide from 4-mercapto-2H-chromene-2-thione is described. The anti-acetylcholinesterase activity of the most important synthons is considered. Ways of constructing six-membered phosphorus-heterocycles via cyclization of Lawesson’s reagent with bifunctional substrates are discussed.

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Published

2011-12-03

Issue

Vol. 1 No. 3 (2011)

Section

Organic Chemistry

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