Characterization of curcumin-nicotine interaction in cetyltrimethyammonium bromide micelle

Authors

  • Maurice O. Iwunze Department of Chemistry, Morgan State University Baltimore, Maryland 21251, USA

DOI:

https://doi.org/10.13171/mjc.3.1.2014.12.04.16

Abstract

A combination of fluorescence and UV-Vis spectrophotometric techniques were used to characterize the interaction of curcumin and nicotine in a cetyltrimethylammonium bromide (CTAB) micellar system. It is observed that in this medium curcumin and nicotine interact in a 1:1 ratio using the UV-Visible molar ration method. The fluorescence spectrophotometric technique, using the Benesi-Hildebrand equation was used to determine the association constant, Ka. The value thus obtained is 1.26 ± 0.02 x 105 M-1 and the molar absorptivity, ε, of 2.3 ±0.06 x 104/M-cm. The free energy of association, △Ga, was subsequently calculated as -29.1 kJ/mol. This vale together with the value obtained for Ka implies that the complex formed by curcumin and nicotine in this medium is not only spontaneous but it also very stable.

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Published

2016-04-12

Issue

Vol. 3 No. 1 (2014)

Section

Physical Chemistry

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