Synthesis and antitubercular evaluation of aryl substituted 2-oxazolines from L-amino acids

Authors

  • Leidiane Araujo de Souza Fiocruz-Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Farmanguinhos. Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 - Rio de Janeiro-RJ.
  • Emerson Teixeira da Silva Fiocruz-Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Farmanguinhos. Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 - Rio de Janeiro-RJ.
  • Maria Cristina Silva Lourenço Instituto de Pesquisas Clínica Evandro Chagas – IPEC – Av. Brasil, 4365 - Manguinhos Rio de Janeiro – RJ
  • Marcus Vini­cius Nora de Souza Fiocruz-Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Farmanguinhos. Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 - Rio de Janeiro-RJ.

DOI:

https://doi.org/10.13171/mjc.2.5.2014.06.01.23

Abstract

This paper describes the synthesis and the in vitro antibacterial activity of a series of twelve substituted aryl-2-oxazolines against Mycobacterium tuberculosis. Seven compounds showed activity and two compounds exhibited a minimal inhibitory concentration (MIC) of 25 ï­g/mL were not cytotoxic for the host cells in cell viability assay. These results could be a good starting point for the development of new antitubercular lead series based on this family of compounds.

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Published

2014-01-06

Issue

Vol. 2 No. 5 (2014)

Section

Medicinal Chemistry

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